Timosaponin AIII ( Timosaponin AIII )

Catalog No. M18529 CAS No. 41059-79-4

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Product Name

Timosaponin AIII
Note

Research use only, not for human use.
Brief Description

Timosaponin AIII induces autophagy in HeLa cells followed by apoptotic cell death (IC50: 10 μM).
Description

Timosaponin AIII induces autophagy in HeLa cells followed by apoptotic cell death (IC50: 10 μM). The Timosaponin AIII cellular response is mediated via inhibition of mTORC1 and induction of ER stress (IC50: 2.5 μM, BT474 cells; 6 μM, MDAMB231). The Timosaponin AIII pro-apoptotic response is selective for tumor cells over normal cells but autophagy is induced in both.
Synonyms

Timosaponin AIII
Pathway

Others
Target

Other Targets
Recptor

mTORC1
Research Area

Others-Field
Indication

——

CAS Number

41059-79-4
Formula Weight

740.92
Molecular Formula

C39H64O13
Purity

98%
Solubility

——
SMILES

[C@]12([C@@H]3[C@H](C[C@H]1[C@H]1[C@H](CC2)[C@@]2([C@H](CC1)C[C@H](CC2)O[C@H]1[C@H](O[C@@H]2O[C@@H]([C@H]([C@@H]([C@H]2O)O)O)CO)[C@H]([C@H]([C@H](O1)CO)O)O)C)O[C@@]1([C@H]3C)CC[C@H](CO1)C)C
Chemical Name

[(25S)-5-Spirostan-3-yl]2-O-(-D-glucopyranosyl)--D-galactopyranoside

1. Wu ZT, et al. Acta Pharmacol Sin. 2014 Sep;35(9):1188-98.

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